Glyphosate pathways to modern diseases V: Amino acid analogue of glycine in diverse proteins

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Glyphosate, a synthetic amino acid and analogue of glycine, is the most widely used biocide on the planet. Its presence in food for human consumption and animal feed is ubiquitous. Epidemiological studies have revealed a strong correlation between the increasing incidence in the United States of a large number of chronic diseases and the increased use of glyphosate herbicide on corn, soy and wheat crops. Glyphosate, acting as a glycine analogue, may be mistakenly incorporated into peptides during protein synthesis. A deep search of the research literature has revealed a number of protein classes that depend on conserved glycine residues for proper function. Glycine, the smallest amino acid, has unique properties that support flexibility and the ability to anchor to the plasma membrane or the cytoskeleton. Glyphosate substitution for conserved glycines can easily explain a link with diabetes, obesity, asthma, chronic obstructive pulmonary disease (COPD), pulmonary edema, adrenal insufficiency, hypothyroidism, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, prion diseases, lupus, mitochondrial disease, non- Hodgkin’s lymphoma, neural tube defects, infertility, hypertension, glaucoma, osteoporosis, fatty liver disease and kidney failure. The correlation data together with the direct biological evidence make a compelling case for glyphosate action as a glycine analogue to account for much of glyphosate’s toxicity. Glufosinate, an analogue of glutamate, likely exhibits an analogous toxicity mechanism. There is an urgent need to find an effective and economical way to grow crops without the use of glyphosate and glufosinate as herbicides.

LINK: https://www.researchgate.net/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins

MORE INFO: https://people.csail.mit.edu/seneff/DC2016/AnthonySamsel_DC2016.pdf

STUDY: https://www.researchgate.net/profile/Anthony_Samsel/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins/links/5787f09f08aecf56ebcb5741.pdf

Glyphosate, 2,4-D And Dicamba Herbicides Cause Antibiotic Resistance

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Scientists have discovered that exposure to three widely used herbicides including Monsanto’s Roundup and Kamba causes pathogenic bacteria to develop resistance to medically important antibiotics.

This is a very important scientific discovery. The study shows that the use of herbicides in intensive farming may be one of the reasons that antibiotic resistance has been increasing so rapidly in recent years.

A team of researchers from universities in New Zealand and Mexico have discovered that three herbicides (weed killers) widely used in agriculture and in gardens can make disease causing bacteria resistant to antibiotics.

Their paper, published in the online journal MBio, offers a new perspective on the problem of antibiotic resistance, which may help to explain why it has been increasing so rapidly in recent years.

The three herbicides they looked at were glyphosate, the world’s most widely used pesticide (formulations are sold by Monsanto as ‘Roundup’), dicamba (Kamba), which is proprietary to Monsanto, and 2,4-D, the active ingredient of the notorious ‘agent orange’ herbicide used by the US military to ‘defoliate’ rainforests in Vietnam and Cambodia in the 1960s.

These were tested on E. coli and Salmonella bacteria treated with one of five different antibiotics: Ciprofloxacin, chloramphenicol, ampicillin, kanamycin and tetracycline. E.coli cause more infections that any other type of bacteria. Both E.coli and Salmonella can cause serious, even fatal, infections.

In most cases even low levels of the herbicides had the effect of inducing antibiotic resistance before the antibiotics had time to kill the bacteria. In a few antibiotic / herbicide combinations they actually made the bacteria more susceptible to the antibiotic, while in other cases they had no impact.

The danger is on-farm, not in food

Continue reading “Glyphosate, 2,4-D And Dicamba Herbicides Cause Antibiotic Resistance”

World Health Organisation Says Most Common Weedkiller ‘Probably’ Causes Cancer

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In March, 2015, 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC; Lyon, France) to assess the carcinogenicity of the organophosphate pesticides tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate (table). These assessments will be published as volume 112 of the IARC Monographs.

Glyphosate is a broad-spectrum herbicide, currently with the highest production volumes of all herbicides. It is used in more than 750 different products for agriculture, forestry, urban, and home applications. Its use has increased sharply with the development of genetically modified glyphosate-resistant crop varieties. Glyphosate has been detected in air during spraying, in water, and in food. There was limited evidence in humans for the carcinogenicity of glyphosate. Case-control studies of occupational exposure in the USA, Canada and Sweden reported increased risks for non-Hodgkin lymphoma that persisted after adjustment for other pesticides. The AHS cohort did not show a significantly increased risk of non-Hodgkin lymphoma. In male CD-1 mice, glyphosate induced a positive trend in the incidence of a rare tumour, renal tubule carcinoma. A second study reported a positive trend for haemangiosarcoma in male mice. Glyphosate increased pancreatic islet-cell adenoma in male rats in two studies. A glyphosate formulation promoted skin tumours in an initiation-promotion study in mice.

Glyphosate has been detected in the blood and urine of agricultural workers, indicating absorption. Soil microbes degrade glyphosate to aminomethylphosphoric acid (AMPA). Blood AMPA detection after poisonings suggests intestinal microbial metabolism in humans. Glyphosate and glyphosate formulations induced DNA and chromosomal damage in mammals, and in human and animal cells in vitro. One study reported increases in blood markers of chromosomal damage (micronuclei) in residents of several communities after spraying of glyphosate formulations. Bacterial mutagenesis tests were negative. Glyphosate, glyphosate formulations, and AMPA induced oxidative stress in rodents and in vitro. The Working Group classified glyphosate as “probably carcinogenic to humans” (Group 2A).

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Continue reading “World Health Organisation Says Most Common Weedkiller ‘Probably’ Causes Cancer”

Dutch Parliament Bans Glyphosate Herbicides For Non-Commercial Use

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From the end of 2015 onward the sale of Glyphosate -based herbicides to private persons, including the World’s number one herbicide ‘Roundup’, will be prohibited in the Netherlands over health fears.

Glyphosate is an ingredient of Roundup, which is sold to private persons as a weed control product. The Dutch Lower House gave consent to a motion by Dutch Member of Parliament Esther Ouwehand, which prohibits the sale of glyphosate to private individuals.

Glyphosate is increasingly associated with health problems such as infertility, birth defects, damage to the nervous system, Parkinson’s disease and several forms of cancer. In addition to health risks for humans, the usage of chemical pesticides can also lead to loss of biodiversity and difficulties with purifying drinking water.

In 2011 the Dutch Lower House asked for a total ban on the use of glyphosate outside the agricultural sector. Municipalities also use this pesticide for weed control and even private persons can buy it everywhere. Contrary to the wish of the Lower House the cabinet made all kinds of exceptions to the requested ban. Private individuals were allowed to use products containing glyphosate in their gardens, but not on their terraces. This is unclear, uncontrollable as well as irresponsible, given all risks to health and environment.

Now that the Party for the Animals motion has been adopted the cabinet has to get pesticides containing glyphosate, such as the commonly-sold RoundUp, off the shelves. Political parties PvdA, CU, 50+, GroenLinks, SP and PVV support the motion by Ouwehand, which she has submitted together with Gerard Schouw (D66).

Esther Ouwehand: “Agricultural pesticides in user-friendly packaging are sold in abundance to private persons. In garden centres RoundUp is promoted as harmless, but unsuspecting customers have no idea what the risks of this product are. Especially children are sensitive to toxic substances and should therefore not be exposed to it.”

The Lower House, led by the Party for the Animals, makes a stand against agricultural pesticides more and more. The Lower House supported motions by Esther Ouwehand for a ban on neonicotinoids, toxins that cause massive bee mortality. Moreover, at the urging of the Party for the Animals measures are being taken to restrict agricultural pesticides in order to protect residents. Ouwehand’s plea has recently been underlined by the Dutch Health Council.

Many people are concerned about the use of glyphosate in their living environment. This is demonstrated by dozens of reports at Gifkikker.nl, the notification centre that the Party for the Animals and foundation Bollenboos launched in April last year. The Dutch Health Council praised this initiative, because up until then civilians who worry about the use of pesticides in their neighbourhood could not turn to anyone with their concerns and complaints.

LINK: http://sustainablepulse.com/2014/04/04/dutch-parliament-bans-glyphosate-herbicides-non-commercial-use/