Glyphosate pathways to modern diseases V: Amino acid analogue of glycine in diverse proteins

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Glyphosate, a synthetic amino acid and analogue of glycine, is the most widely used biocide on the planet. Its presence in food for human consumption and animal feed is ubiquitous. Epidemiological studies have revealed a strong correlation between the increasing incidence in the United States of a large number of chronic diseases and the increased use of glyphosate herbicide on corn, soy and wheat crops. Glyphosate, acting as a glycine analogue, may be mistakenly incorporated into peptides during protein synthesis. A deep search of the research literature has revealed a number of protein classes that depend on conserved glycine residues for proper function. Glycine, the smallest amino acid, has unique properties that support flexibility and the ability to anchor to the plasma membrane or the cytoskeleton. Glyphosate substitution for conserved glycines can easily explain a link with diabetes, obesity, asthma, chronic obstructive pulmonary disease (COPD), pulmonary edema, adrenal insufficiency, hypothyroidism, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, prion diseases, lupus, mitochondrial disease, non- Hodgkin’s lymphoma, neural tube defects, infertility, hypertension, glaucoma, osteoporosis, fatty liver disease and kidney failure. The correlation data together with the direct biological evidence make a compelling case for glyphosate action as a glycine analogue to account for much of glyphosate’s toxicity. Glufosinate, an analogue of glutamate, likely exhibits an analogous toxicity mechanism. There is an urgent need to find an effective and economical way to grow crops without the use of glyphosate and glufosinate as herbicides.

LINK: https://www.researchgate.net/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins

MORE INFO: https://people.csail.mit.edu/seneff/DC2016/AnthonySamsel_DC2016.pdf

STUDY: https://www.researchgate.net/profile/Anthony_Samsel/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins/links/5787f09f08aecf56ebcb5741.pdf

Glyphosate Causes Liver Disease?

spraying-pesticides

A new cutting edge study from Kings College, London has found that residues of popular weedkiller glyphosate found in food can cause fatty liver disease. This is another huge blow for glyphosate, but is it the final nail in the coffin?

Glyphosate is the world’s most widely sold weedkiller, commonly found in Monsanto’s Roundup, and we’re fighting to ban it as a pre-harvest treatment. Glyphosate is sprayed on our wheat and other cereals just before harvest – mainly to allow machines to go a little faster. From there it follows the grain into our bread; recent testing by the Defra Committee on Pesticide Residues in Food (PRiF) found that almost two thirds of wholemeal bread sampled contained glyphosate. Supermarkets and bread manufacturers say this is quite OK as Roundup is usually below official safety levels.

However, this new peer-reviewed study, led by Dr Michael Antoniou at King’s College London, has found that weedkillers like Roundup cause non-alcoholic fatty liver disease at very low doses, thousands of times below levels permitted by regulators worldwide. This research is the first evidence of a clear causative link between consumption of Roundup – at levels that are found in the real world – and a serious disease. It follows previous findings from the World Health Organisation’s International Agency for Research on Cancer, who concluded that glyphosate is a ‘probable carcinogen’.

It is extraordinary that glyphosate, in use for decades, has only now been recognised as a cause of the liver disease NAFLD (non-alcoholic fatty liver disease), which can cause fatigue, weakness, weight loss, loss of appetite, nausea, abdominal pain, spider-like blood vessels, yellowing of the skin and eyes (jaundice), itching, fluid build-up and swelling of the legs and abdomen, and mental confusion.

The study was conducted over two years, where rats were administered a very low daily dose of four nanograms per kilogram of bodyweight per day. To put that into perspective that is 75,000 times below the levels of glyphosate permitted by the EU in our food. According to lead researcher Dr Michael Antoniou, previous studies on human urine found that we often consume around a thousand times the amount of glyphosate the rats consumed. Regulators globally accept toxicity studies in rats as indicators of human health risk, making this a significant, and truly disturbing, discovery.

The news about Roundup comes just as France announces an official ban on the use of all harmful chemicals in outdoor places where young children, crucial pollinators and the general public frequently gather – the ban covers all public parks, gardens and forests including famed Parisian green spaces like Jardin des Tuileries, Bois de Vincennes and Jardin de Luxembourg. Only French cemeteries and sports stadiums are exempt. In 2019, the law will be extended to private gardens. These national moves follow cities like Lyon, France’s third-largest, and Strasbourg, which have kept all their public parks and gardens (300 in Lyon alone) pesticide-free since 2008.

We need to get this poisonous weedkiller out of our bread, and out of our bodies. We are calling for an end to spraying Glyphosate on crops just before they are harvested, and you can join the fight by joining us or writing to your local MP. This new study raises serious concerns for human health and must be taken seriously by Monsanto and the government; with enough pressure we can ensure it is the final nail in the coffin for glyphosate.

LINK: https://www.soilassociation.org/blogs/2017/january/glyphosate-weedkiller-causes-liver-disease/

STUDY: http://www.nature.com/articles/srep39328

 

What Is Chromium-6 And How Did It Infiltrate America’s Drinking Water?

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Chromium-6, the cancer-causing chemical best known for its role in the Erin Brockovich story, has been found at higher-than-recommended levels in the tap water supplying two-thirds of all Americans, according to a report from the Environmental Working Group.
EWG, a nonprofit research organization, analyzed Environmental Protection Agency data on more than 60,000 samples collected at water utilities in all 50 states between 2013 and 2015. They found chromium-6 at levels deemed unsafe by public health officials.

“Americans deserve to know if there are potentially harmful levels of a cancer-causing chemical in their tap water,” David Andrews, a senior scientist at EWG and co-author of the report, told the PBS NewsHour.
Chromium-6 occurs naturally in the environment, but high quantities are also produced by industrial projects. Pollution can occur when these industrial sites fail to follow proper waste disposal methods, such as with unlined coal ash ponds.
“The difficulty with chromium-6 is how to set a standard to protect human health during windows of development,” Andrews said.
Even in small amounts, chromium-6 can cause skin burns, pneumonia, complications during childbirth and stomach cancer.

Continue reading “What Is Chromium-6 And How Did It Infiltrate America’s Drinking Water?”

Glyphosate, 2,4-D And Dicamba Herbicides Cause Antibiotic Resistance

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Scientists have discovered that exposure to three widely used herbicides including Monsanto’s Roundup and Kamba causes pathogenic bacteria to develop resistance to medically important antibiotics.

This is a very important scientific discovery. The study shows that the use of herbicides in intensive farming may be one of the reasons that antibiotic resistance has been increasing so rapidly in recent years.

A team of researchers from universities in New Zealand and Mexico have discovered that three herbicides (weed killers) widely used in agriculture and in gardens can make disease causing bacteria resistant to antibiotics.

Their paper, published in the online journal MBio, offers a new perspective on the problem of antibiotic resistance, which may help to explain why it has been increasing so rapidly in recent years.

The three herbicides they looked at were glyphosate, the world’s most widely used pesticide (formulations are sold by Monsanto as ‘Roundup’), dicamba (Kamba), which is proprietary to Monsanto, and 2,4-D, the active ingredient of the notorious ‘agent orange’ herbicide used by the US military to ‘defoliate’ rainforests in Vietnam and Cambodia in the 1960s.

These were tested on E. coli and Salmonella bacteria treated with one of five different antibiotics: Ciprofloxacin, chloramphenicol, ampicillin, kanamycin and tetracycline. E.coli cause more infections that any other type of bacteria. Both E.coli and Salmonella can cause serious, even fatal, infections.

In most cases even low levels of the herbicides had the effect of inducing antibiotic resistance before the antibiotics had time to kill the bacteria. In a few antibiotic / herbicide combinations they actually made the bacteria more susceptible to the antibiotic, while in other cases they had no impact.

The danger is on-farm, not in food

Continue reading “Glyphosate, 2,4-D And Dicamba Herbicides Cause Antibiotic Resistance”

Health Costs Of Hormone Disrupting Chemicals Over €150bn A Year In Europe

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Lower IQ, adult obesity and 5% of autism cases are all linked to exposure to endocrine disruptors found in food containers, plastics, furniture, toys, carpeting and cosmetics, says new expert study

Scientists recommend against pregnant women and children using plastic containers for food, especially in the microwave due to endocrine disruptors.

Europe is experiencing an explosion in health costs caused by endocrine-disrupting chemicals (EDCs) that is comparable to the cost of lead and mercury poisoning, according to the most comprehensive study of the subject yet published.

Endocrine disruptors are chemicals that interfere with the human hormone system, and can be found in food containers, plastics, furniture, toys, carpeting and cosmetics.

The new series of reports by 18 of the world’s foremost experts on endocrine science pegs the health costs of exposure to them at between €157bn-€270bn (£113bn-£195bn), or at least 1.23% of the continent’s GDP.

“The shocking thing is that the major component of that cost is related to the loss of brain function in the next generation,” one of the report’s authors, Professor Philippe Grandjean of Harvard University, told the Guardian.

“Our brains need particular hormones to develop normally – the thyroid hormone and sex hormones like testosterone and oestrogen. They’re very important in pregnancy and a child can very well be mentally retarded because of a lack of iodine and the thyroid hormone caused by chemical exposure.”

After IQ loss, adult obesity linked to exposure to phthalates, a group of chemicals used in plastics, was the second largest part of the overall cost, with an estimated price tag of €15.6bn a year, according to the paper, which was published on Thursday in the Endocrine Society’s Journal of Clinical Endocrinology and Metabolism.

The study attributes at least 5% of European autism cases to EDC exposure, but Grandjean said the figure likely under-estimated the linkage, because of difficulties in measuring foetal exposure to chemicals after a child had been born.

“I would recommend that pregnant women and children eat organic fruits and vegetables and avoid using plastic containers and canned food, especially in the microwave, because containers are usually treated on the inside with substances and compounds that can leak into the tomato soup and may act as endocrine disruptors,” he said.

Continue reading “Health Costs Of Hormone Disrupting Chemicals Over €150bn A Year In Europe”